Publication list

Sachslehner AP, Steinbinder J, Hess C, Mlitz V, Eckhart L. The Epithelial Egg Tooth of the Chicken Shares Protein Markers with the Embryonic Subperiderm and Feathers. J Dev Biol. 2025 Dec 22;14(1):1. doi: 10.3390/jdb14010001. PMID: 41562861; PMCID: PMC12821399.  

Sachslehner AP, Lachner J, Mlitz V, Golabi B, Hess C, Sipos W, Eckhart L. Comparative Transcriptomics Reveals a Dual Role of the Epidermal Differentiation Complex in the Skin and the Oesophagus. Exp Dermatol. 2025 Dec;34(12):e70181. doi: 10.1111/exd.70181. PMID: 41319262; PMCID: PMC12665336.

Dörner C, Steinbinder J, Sachslehner AP, Sukseree S, Eckhart L. Amino Acid Metabolism of the Skin: Control by Specific Enzymes and Contribution to Protective Functions. Metabolites. 2025 Sep 9;15(9):601. doi: 10.3390/metabo15090601. PMID: 41002986; PMCID: PMC12471417.  

Eckhart L, Sachslehner AP, Steinbinder J, Fischer H. Caspase-14-like Proteases: An Epidermal Caspase and Its Evolutionarily Ancient Relatives. Biomolecules. 2025 Jun 22;15(7):913. doi: 10.3390/biom15070913. PMID: 40723785; PMCID: PMC12292325.  

Sachslehner AP, Parry DAD, Eckhart L. Cornified Epithelial Teeth of Jawless Vertebrates Contain Proteins Similar to Keratin-Associated Proteins of Mammalian Skin Appendages. J Dev Biol. 2025 May 19;13(2):18. doi: 10.3390/jdb13020018. PMID: 40407687; PMCID: PMC12101200.  

María Torres-Sánchez, Sandra Goutte, H Christoph Liedtke, Steven JR Allain,  Md Sabbir Ahammed, Natalie Calatayud, Aaron Comeault, Kathryn Elmer,  Paula C Eterovick, Edward Gilbert, Juan M Guayasamin, Melissa Hernández-Poveda, Ramachandran Kotharambath, Pablo Lechuga Paredes, Cuckoo Mahapatra, Kevin P Mulder, Junior Nadaline, Elnaz Najafi-Majd, Nicolas Pollet, Andrew O Rubio, Attila Placido Sachslehner, Laura Sanz-Sobrino, Karen Siu-Ting, Anthony A Snead, Nicholas Strowbridge, Gonçalo Espregueira Themudo, Daniel Vivas Barreto, Guinevere OU Wogan, Katharina C Wollenberg Valero, Amphibian Genomics Consortium. Comparative biology needs de novo transcriptome assemblies: drawing attention towards amphibians. Amphibia-Reptilia 2025 April 30, 1-19. doi.org/10.1163/15685381-bja10232  

Eckhart L, Sachslehner AP, Steinbinder J, Fischer H. Caspase Domain Duplication During the Evolution of Caspase-16. J Mol Evol. 2025 May 20. doi: 10.1007/s00239-025-10252-w. Epub ahead of print. PMID: 40392285.  

Holthaus KB, Steinbinder J, Sachslehner AP, Eckhart L. Skin Appendage Proteins of Tetrapods: Building Blocks of Claws, Feathers, Hair and Other Cornified Epithelial Structures. Animals (Basel). 2025 Feb 6;15(3):457. doi: 10.3390/ani15030457. PMID: 39943227; PMCID: PMC11816140.  

Sachslehner AP, Eckhart L. Convergent Evolution of Cysteine-Rich Keratins in Horny Teeth of Jawless Vertebrates and in Cornified Skin Appendages of Amniotes. Mol Biol Evol. 2025 Feb 3;42(2):msaf028. doi: 10.1093/molbev/msaf028. PMID: 39891703; PMCID: PMC11850651.  

Holthaus KB, Steinbinder J, Sachslehner AP, Eckhart L. Convergent Evolution Has Led to the Loss of Claw Proteins in Snakes and Worm Lizards. Genome Biol Evol. 2025 Jan 6;17(1):evae274. doi: 10.1093/gbe/evae274. PMID: 39696999; PMCID: PMC11704414.  

Holthaus KB, Sachslehner AP, Steinbinder J, Eckhart L. Epidermal Differentiation Genes of the Common Wall Lizard Encode Proteins with Extremely Biased Amino Acid Contents. Genes (Basel). 2024 Aug 28;15(9):1136. doi: 10.3390/genes15091136. PMID: 39336727; PMCID: PMC11431283.  

Eckhart L, Holthaus KB, Sachslehner AP. Cell differentiation in the embryonic periderm and in scaffolding epithelia of skin appendages. Dev Biol. 2024 Nov;515:60-66. doi: 10.1016/j.ydbio.2024.07.002. Epub 2024 Jul 2. PMID: 38964706.  

Sachslehner AP, Surbek M, Holthaus KB, Steinbinder J, Golabi B, Hess C, Eckhart L. The Evolution of Transglutaminases Underlies the Origin and Loss of Cornified Skin Appendages in Vertebrates. Mol Biol Evol. 2024 Jun 1;41(6):msae100. doi: 10.1093/molbev/msae100. PMID: 38781495; PMCID: PMC11152450.  

Steinbinder J, Sachslehner AP, Holthaus KB, Eckhart L. Comparative genomics of sirenians reveals evolution of filaggrin and caspase-14 upon adaptation of the epidermis to aquatic life. Sci Rep. 2024 Apr 23;14(1):9278. doi: 10.1038/s41598-024-60099-2. PMID: 38653760; PMCID: PMC11039687.  

Carron M, Sachslehner AP, Cicekdal MB, Bruggeman I, Demuynck S, Golabi B, De Baere E, Declercq W, Tschachler E, Vleminckx K, Eckhart L. Evolutionary origin of Hoxc13-dependent skin appendages in amphibians. Nat Commun. 2024 Mar 18;15(1):2328. doi: 10.1038/s41467-024-46373-x. PMID: 38499530; PMCID: PMC10948813.  

Steinbinder J, Sachslehner AP, Holthaus KB, Eckhart L. Comparative genomics of monotremes provides insights into the early evolution of mammalian epidermal differentiation genes. Sci Rep. 2024 Jan 16;14(1):1437. doi: 10.1038/s41598-024-51926-7. PMID: 38228724; PMCID: PMC10791643.  

Surbek M, Van de Steene T, Sachslehner AP, Golabi B, Griss J, Eyckerman S, Gevaert K, Eckhart L. Cornification of keratinocytes is associated with differential changes in the catalytic activity and the immunoreactivity of transglutaminase-1. Sci Rep. 2023 Dec 6;13(1):21550. doi: 10.1038/s41598-023-48856-1. PMID: 38057394; PMCID: PMC10700374.  

Surbek M, Sukseree S, Sachslehner AP, Copic D, Golabi B, Nagelreiter IM, Tschachler E, Eckhart L. Heme Oxygenase-1 Is Upregulated during Differentiation of Keratinocytes but Its Expression Is Dispensable for Cornification of Murine Epidermis. J Dev Biol. 2023 Mar 10;11(1):12. doi: 10.3390/jdb11010012. PMID: 36976101; PMCID: PMC10058925.  

Sachslehner AP, Surbek M, Golabi B, Geiselhofer M, Jäger K, Hess C, Kuchler U, Gruber R, Eckhart L. Transglutaminase Activity Is Conserved in Stratified Epithelia and Skin Appendages of Mammals and Birds. Int J Mol Sci. 2023 Jan 22;24(3):2193. doi: 10.3390/ijms24032193. PMID: 36768511; PMCID: PMC9916842.  

Sachslehner AP, Eckhart L. Evolutionary diversification of epidermal barrier genes in amphibians. Sci Rep. 2022 Aug 10;12(1):13634. doi: 10.1038/s41598-022-18053-7. PMID: 35948609; PMCID: PMC9365767.  

Sachslehner AP, Surbek M, Lachner J, Paudel S, Eckhart L. Identification of Chicken Transglutaminase 1 and In Situ Localization of Transglutaminase Activity in Avian Skin and Esophagus. Genes (Basel). 2021 Sep 30;12(10):1565. doi: 10.3390/genes12101565. PMID: 34680960; PMCID: PMC8535770.  

Sachslehner A, Zieger E, Calcino A, Wanninger A. HES and Mox genes are expressed during early mesoderm formation in a mollusk with putative ancestral features. Sci Rep. 2021 Sep 9;11(1):18030. doi: 10.1038/s41598-021-96711-y. PMID: 34504115; PMCID: PMC8429573.