Mihaela Pavličev
Univ.-Prof. Mag. Dr.
Deputy Head of the Department of Evolutionary Biology
Head of the Unit for Theoretical Biology
phone +43-1-4277-56700
mihaela.pavlicev@univie.ac.at
About me
My foremost interest is in the organismal features that enable evolvability of complex organisms. To understand phenotypic evolution, we need to understand what patterns of heritable phenotypic variation the developmental/physiological systems are able to produce, what are the consequences of specific patterns of variation over short terms (population genetic scale) and long terms (species divergence observed in comparative biology) under selection and drift, and how the patterns of variation themselves evolve.
One recurring evolutionary phenomenon is the decoupling of variation between traits, and subsequent individuation of parts and the origin of new biological units. In this context, my work pertains to the role of pleiotropy and interactions in this process.
I pursue these questions of evolvability and individuation in theory as well as in empirical work on the evolution of limbs and of the mammalian female reproductive system.
Publications
2020
Pavličev, M., Romero, R., & Mitteroecker, P. (2020). Evolution of the human pelvis and obstructed labor: new explanations of an old obstetrical dilemma. American Journal of Obstetrics and Gynecology, 222(1), 3-16. doi.org/10.1016/j.ajog.2019.06.043
Zhang, X., Pavlicev, M., Jones, H. N., & Muglia, L. J. (2020). Eutherian-specific gene TRIML2 attenuates inflammation in the evolution of placentation. Molecular Biology and Evolution, 37(2), 507–523. doi.org/10.1093/molbev/msz238
2019
Griffith, O. W., Chavan, A. R., Pavlicev, M., Protopapas, S., Callahan, R., Maziarz, J., & Wagner, G. P. (2019). Endometrial recognition of pregnancy occurs in the grey short-tailed opossum ( Monodelphis domestica). Proceedings of the Royal Society B: Biological Sciences, 286(1905), 20190691. doi.org/10.1098/rspb.2019.0691
Hansen, T. F., Solvin, T. M., & Pavlicev, M. (2019). Predicting evolutionary potential: A numerical test of evolvability measures. Evolution, 73(4), 689-703. doi.org/10.1111/evo.13705
Kshitiz, Afzal, J., Maziarz, J. D., Hamidzadeh, A., Liang, C., Erkenbrack, E. M., Nam, H., Haeger, J-D., Pfarrer, C., Hoang, T., Ott, T., Spencer, T., Pavličev, M., Antczak, D. F., Levchenko, A., & Wagner, G. P. (2019). Evolution of placental invasion and cancer metastasis are causally linked. Nature Ecology & Evolution, 3(12), 1743-1753. doi.org/10.1038/s41559-019-1046-4
Pavlicev, M., Zupan, A. M., Barry, A., Walters, S., Milano, K. M., Kliman, H. J., & Wagner, G. P. (2019). An experimental test of the ovulatory homolog model of female orgasm. Proceedings of the National Academy of Sciences of the United States of America, 116(41), 20267-20273. doi.org/10.1073/pnas.1910295116
Rytkönen, K. T., Erkenbrack, E. M., Poutanen, M., Elo, L. L., Pavlicev, M., & Wagner, G. P. (2019). Decidualization of Human Endometrial Stromal Fibroblasts is a Multiphasic Process Involving Distinct Transcriptional Programs. Reproductive Sciences (RS), 26(3), 323-336. doi.org/10.1177/1933719118802056
Sahu, B. S., Rodriguez, P., Nguyen, M. E., Han, R., Cero, C., Razzoli, M., Piaggi, P., Laskowski, L. J., Pavlicev, M., Muglia, L., Mahata, S. K., O'Grady, S., McCorvy, J. D., Baier, L. J., Sham, Y. Y., & Bartolomucci, A. (2019). Peptide/Receptor Co-evolution Explains the Lipolytic Function of the Neuropeptide TLQP-21. Cell Reports, 28(10), 2567-2580.e6. doi.org/10.1016/j.celrep.2019.07.101
Wagner, G. P., & Pavlicev, M. (2019). Reply to Quintana et al. Behavior is an unlikely mediator of fluoxetine effects on ovulation in rabbits. Proceedings of the National Academy of Sciences of the United States of America, 116(51), 25384-25385. doi.org/10.1073/pnas.1918440116
2018
Dunn-Fletcher, C. E., Muglia, L. M., Pavlicev, M., Wolf, G., Sun, M-A., Hu, Y-C., Huffman, E., Tumukuntala, S., Thiele, K., Mukherjee, A., Zoubovsky, S., Zhang, X., Swaggart, K. A., Lamm, K. Y. B., Jones, H., Macfarlan, T. S., & Muglia, L. J. (2018). Anthropoid primate-specific retroviral element THE1B controls expression of CRH in placenta and alters gestation length. PLoS Biology, 16(9), e2006337. doi.org/10.1371/journal.pbio.2006337
Kennedy, J., & Pavličev, M. (2018). Female orgasm and the emergence of prosocial empathy: An evo-devo perspective. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 330(2), 66-75. doi.org/10.1002/jez.b.22795
Pavlicev, M., & Norwitz, E. R. (2018). Human Parturition: Nothing More Than a Delayed Menstruation. Reproductive Sciences (RS), 25(2), 166-173. doi.org/10.1177/1933719117725830
2017
Mitteroecker, P., Windhager, S., & Pavlicev, M. (2017). Cliff-edge model predicts intergenerational predisposition to dystocia and Caesarean delivery. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 114(44), 11669-11672. doi.org/10.1073/pnas.1712203114
Mitteroecker, P., Huttegger, S. M., Fischer, B., & Pavlicev, M. (2017). Reply to Grossman: The role of natural selection for the increase of Caesarean section rates. Proceedings of the National Academy of Sciences of the United States of America, 114(8), E1305. doi.org/10.1073/pnas.1621176114
Pavličev, M., Wagner, G. P., Chavan, A. R., Owens, K., Maziarz, J., Dunn-Fletcher, C., Kallapur, S. G., Muglia, L., & Jones, H. (2017). Single-cell transcriptomics of the human placenta: inferring the cell communication network of the maternal-fetal interface. Genome Research, 27(3), 349-361. doi.org/10.1101/gr.207597.116
Simonti, C. N., Pavlicev, M., & Capra, J. A. (2017). Transposable Element Exaptation into Regulatory Regions Is Rare, Influenced by Evolutionary Age, and Subject to Pleiotropic Constraints. Molecular Biology and Evolution, 34(11), 2856-2869. doi.org/10.1093/molbev/msx219
Wagner, G. P., & Pavličev, M. (2017). Origin, Function, and Effects of Female Orgasm: All Three are Different. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 328(4), 299-303. doi.org/10.1002/jez.b.22737
Zhang, G., Feenstra, B., Bacelis, J., Liu, X., Muglia, L. M., Juodakis, J., Miller, D. E., Litterman, N., Jiang, P. P., Russell, L., Hinds, D. A., Hu, Y., Weirauch, M. T., Chen, X., Chavan, A. R., Wagner, G. P., Pavličev, M., Nnamani, M. C., Maziarz, J., ... Muglia, L. J. (2017). Genetic Associations with Gestational Duration and Spontaneous Preterm Birth. New England Journal of Medicine, 377(12), 1156-1167. doi.org/10.1056/NEJMoa1612665
2016
Arendt, D., Musser, J. M., Baker, C. V. H., Bergman, A., Cepko, C., Erwin, D. H., Pavlicev, M., Schlosser, G., Widder, S., Laubichler, M. D., & Wagner, G. P. (2016). The origin and evolution of cell types. Nature Reviews. Genetics, 17(12), 744-757. doi.org/10.1038/nrg.2016.127
Eidem, H. R., Rinker, D. C., Ackerman, W. E., Buhimschi, I. A., Buhimschi, C. S., Dunn-Fletcher, C., Kallapur, S. G., Pavličev, M., Muglia, L. J., Abbot, P., & Rokas, A. (2016). Comparing human and macaque placental transcriptomes to disentangle preterm birth pathology from gestational age effects. Placenta, 41, 74-82. doi.org/10.1016/j.placenta.2016.03.006