Mihaela Pavličev
Univ.-Prof. Mag. Dr.
Deputy Head of the Department of Evolutionary Biology
Head of the Unit for Theoretical Biology
phone +43-1-4277-56700
mihaela.pavlicev@univie.ac.at
About me
My foremost interest is in the organismal features that enable evolvability of complex organisms. To understand phenotypic evolution, we need to understand what patterns of heritable phenotypic variation the developmental/physiological systems are able to produce, what are the consequences of specific patterns of variation over short terms (population genetic scale) and long terms (species divergence observed in comparative biology) under selection and drift, and how the patterns of variation themselves evolve.
One recurring evolutionary phenomenon is the decoupling of variation between traits, and subsequent individuation of parts and the origin of new biological units. In this context, my work pertains to the role of pleiotropy and interactions in this process.
I pursue these questions of evolvability and individuation in theory as well as in empirical work on the evolution of limbs and of the mammalian female reproductive system.
Publications
Showing entries 41 - 60 out of 76
2016
Mitteroecker, P., Cheverud, J. M., & Pavlicev, M. (2016). Multivariate Analysis of Genotype-Phenotype Association. Genetics: a periodical record of investigations bearing on heredity and variation, 202(4), 1345-1363. https://doi.org/10.1534/genetics.115.181339
Pavličev, M., Mitteroecker, P., Gonzalez, P. M., Rolian, C., Jamniczky, H., Villena, F. P. M., Marcucio, R., Spritz, R., & Hallgrimsson, B. (2016). Development Shapes a Consistent Inbreeding Effect in Mouse Crania of Different Line Crosses. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 326(8), 474-488. https://doi.org/10.1002/jez.b.22722
Pavličev, M., & Wagner, G. (2016). The Evolutionary Origin of Female Orgasm. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 326(6), 326-337. https://doi.org/10.1002/jez.b.22690
2015
Pavlicev, M., Hiratsuka, K., Swaggart, K. A., Dunn, C., & Muglia, L. (2015). Detecting endogenous retrovirus-driven tissue-specific gene transcription. Genome Biology and Evolution, 7(4), 1082-1097. https://doi.org/10.1093/gbe/evv049
Pavlicev, M., & Widder, S. (2015). Wiring for Independence: Positive Feedback Motifs Facilitate Individuation of Traits in Development and Evolution. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 324(2), 104-113. https://doi.org/10.1002/jez.b.22612
Pavličev, M., & Cheverud, J. M. (2015). Constraints Evolve: Context Dependency of Gene Effects Allows Evolution of Pleiotropy. Annual Review of Ecology, Evolution, and Systematics, 46, 413-434. https://doi.org/10.1146/annurev-ecolsys-120213-091721
Pavličev, M., & Wagner, G. P. (2015). Evolutionary Systems Biology: Shifting Focus to the Context-Dependency of Genetic Effects. In Integrative Organismal Biology (pp. 91-108) https://doi.org/10.1002/9781118398814.ch6
Swaggart, K. A., Pavlicev, M., & Muglia, L. J. (2015). Genomics of preterm birth. In Cold Spring Harbor Perspectives in Medicine (2 ed., Vol. 5, pp. a023127) https://doi.org/10.1101/cshperspect.a023127
2014
Newman, T., Lengyel, C., Pavlicev, M., & Muglia, L. J. (2014). Human evolution, genomics, and birth timing: New approaches for investigating preterm birth. NeoReviews, 15(1), e17-e27. https://doi.org/10.1542/neo.15-1-e17
Wagner, G. P., Kin, K., Muglia, L., & Pavlicev, M. (2014). Evolution of mammalian pregnancy and the origin of the decidual stromal cell. The International Journal of Developmental Biology, 58(2-4), 117-126. https://doi.org/10.1387/ijdb.130335gw
Watson, R. A., Wagner, G. P., Pavlicev, M., Weinreich, D. M., & Mills, R. (2014). The evolution of phenotypic correlations and "developmental memory". Evolution, 68(4), 1124-1138. https://doi.org/10.1111/evo.12337
2013
Pavlicev, M., Wagner, G. P., Noonan, J. P., Hallgrimsson, B., & Cheverud, J. M. (2013). Genomic Correlates of Relationship QTL Involved in Fore- versus Hind Limb Divergence in Mice. Genome Biology and Evolution, 5(10), 1926-1936. https://doi.org/10.1093/gbe/evt144
Pelabon, C., Bolstad, G. H., Egset, C. K., Cheverud, J. M., Pavlicev, M., & Rosenqvist, G. (2013). On the Relationship between Ontogenetic and Static Allometry. The American Naturalist: a bi-monthly journal devoted to the advancement and correlation of the biological sciences, 181(2), 195-212. https://doi.org/10.1086/668820
2012
Carson, E. A., Kenney-Hunt, J. P., Pavlicev, M., Bouckaert, K. A., Chinn, A. J., Silva, M. J., & Cheverud, J. M. (2012). Weak genetic relationship between trabecular bone morphology and obesity in mice. Bone, 51(1), 46-53. https://doi.org/10.1016/j.bone.2012.03.031
Pavlicev, M., & Wagner, G. P. (2012). A model of developmental evolution: selection, pleiotropy and compensation. Trends in Ecology and Evolution, 27(6), 316-322. https://doi.org/10.1016/j.tree.2012.01.016
Pavlicev, M., & Wagner, G. P. (2012). Coming to grips with evolvability. Evolution: Education and Outreach, 5, 231-244.
Pavlicev, M., Carson, A., Cheverud, J. M., Silva, M., Bouckaert, K., Chinn, A., & Kenney-Hunt, J. (2012). Weak genetic relationship between trabecular bone morphology, and obesity. Bone, 51, 46-53.
2011
Pavlicev, M., Cheverud, J. M., & Wagner, G. P. (2011). Evolution of adaptive phenotypic variation patterns by direct selection for evolvability. Proceedings of the Royal Society of London B: Biological Sciences, 278(1713), 1903-12. https://doi.org/10.1098/rspb.2010.2113
Pavlicev, M., Norgard, E. A., Fawcett, G. L., & Cheverud, J. M. (2011). Evolution of pleiotropy: epistatic interaction pattern supports a mechanistic model underlying variation in genotype-phenotype map. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 316(5), 371-85. https://doi.org/10.1002/jez.b.21410
Pavlicev, M., & Hansen, T. F. (2011). Genotype-Phenotype Maps Maximizing Evolvability: Modularity Revisited. Evolutionary Biology. https://doi.org/10.1007/s11692-011-9136-5
Showing entries 41 - 60 out of 76