Mihaela Pavličev
Univ.-Prof. Mag. Dr.
Deputy Head of the Department of Evolutionary Biology
Head of the Unit for Theoretical Biology
phone +43-1-4277-56700
mihaela.pavlicev@univie.ac.at
About me
My foremost interest is in the organismal features that enable evolvability of complex organisms. To understand phenotypic evolution, we need to understand what patterns of heritable phenotypic variation the developmental/physiological systems are able to produce, what are the consequences of specific patterns of variation over short terms (population genetic scale) and long terms (species divergence observed in comparative biology) under selection and drift, and how the patterns of variation themselves evolve.
One recurring evolutionary phenomenon is the decoupling of variation between traits, and subsequent individuation of parts and the origin of new biological units. In this context, my work pertains to the role of pleiotropy and interactions in this process.
I pursue these questions of evolvability and individuation in theory as well as in empirical work on the evolution of limbs and of the mammalian female reproductive system.
Publications
Showing entries 41 - 60 out of 64
2014
Wagner, G. P., Kin, K., Muglia, L., & Pavlicev, M. (2014). Evolution of mammalian pregnancy and the origin of the decidual stromal cell. The International Journal of Developmental Biology, 58(2-4), 117-126. https://doi.org/10.1387/ijdb.130335gw
Watson, R. A., Wagner, G. P., Pavlicev, M., Weinreich, D. M., & Mills, R. (2014). The evolution of phenotypic correlations and "developmental memory". Evolution, 68(4), 1124-1138. https://doi.org/10.1111/evo.12337
2013
Pavlicev, M., Wagner, G. P., Noonan, J. P., Hallgrimsson, B., & Cheverud, J. M. (2013). Genomic Correlates of Relationship QTL Involved in Fore- versus Hind Limb Divergence in Mice. Genome Biology and Evolution, 5(10), 1926-1936. https://doi.org/10.1093/gbe/evt144
Pelabon, C., Bolstad, G. H., Egset, C. K., Cheverud, J. M., Pavlicev, M., & Rosenqvist, G. (2013). On the Relationship between Ontogenetic and Static Allometry. The American Naturalist: a bi-monthly journal devoted to the advancement and correlation of the biological sciences, 181(2), 195-212. https://doi.org/10.1086/668820
2012
Carson, E. A., Kenney-Hunt, J. P., Pavlicev, M., Bouckaert, K. A., Chinn, A. J., Silva, M. J., & Cheverud, J. M. (2012). Weak genetic relationship between trabecular bone morphology and obesity in mice. Bone, 51(1), 46-53. https://doi.org/10.1016/j.bone.2012.03.031
Pavlicev, M., & Wagner, G. P. (2012). A model of developmental evolution: selection, pleiotropy and compensation. Trends in Ecology and Evolution, 27(6), 316-322. https://doi.org/10.1016/j.tree.2012.01.016
Pavlicev, M., & Wagner, G. P. (2012). Coming to grips with evolvability. Evolution: Education and Outreach, 5, 231-244.
Pavlicev, M., Carson, A., Cheverud, J. M., Silva, M., Bouckaert, K., Chinn, A., & Kenney-Hunt, J. (2012). Weak genetic relationship between trabecular bone morphology, and obesity. Bone, 51, 46-53.
2011
Pavlicev, M., Cheverud, J. M., & Wagner, G. P. (2011). Evolution of adaptive phenotypic variation patterns by direct selection for evolvability. Proceedings of the Royal Society of London B: Biological Sciences, 278(1713), 1903-12. https://doi.org/10.1098/rspb.2010.2113
Pavlicev, M., Norgard, E. A., Fawcett, G. L., & Cheverud, J. M. (2011). Evolution of pleiotropy: epistatic interaction pattern supports a mechanistic model underlying variation in genotype-phenotype map. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 316(5), 371-85. https://doi.org/10.1002/jez.b.21410
2010
Cheverud, J. M., Fawcett, G. L., Jarvis, J. P., Norgard, E. A., Pavlicev, M., Pletscher, L. S., Polonsky, K. S., Ye, H., Bell, G. I., & Semenkovich, C. F. (2010). Calpain-10 is a component of the obesity-related quantitative trait locus Adip1. Journal of Lipid Research, 51(5), 907-13. https://doi.org/10.1194/jlr.M900128
Pavlicev, M., Le Rouzic, A., Cheverud, J. M., Wagner, G. P., & Hansen, T. F. (2010). Directionality of epistasis in a murine intercross population. Genetics, 185(4), 1489-505. https://doi.org/10.1534/genetics.110.118356
2009
Cadahía, L., Pinsker, W., Negro, J. J., Pavlicev, M., Urios, V., & Haring, E. (2009). Repeated sequence homogenization between the control and pseudo-control regions in the mitochondrial genomes of the subfamily Aquilinae. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 312B(3), 171-85. https://doi.org/10.1002/jez.b.21282
Muraoka, Y., Schulze, C., Pavlicev, M., Haring, E., & Wichmann, G. (2009). Spring migration dynamics and sex-specific patterns in stopover strategy in the wood sandpiper Tringa glareola. Journal of Ornithology, 150, 313-319.
Pavlicev, M., & Mayer, W. (2009). Fast radiation of the subfamily Lacertinae (Reptilia: Lacertidae): history or methodical artefact? Molecular Phylogenetics and Evolution, 52(3), 727-34. https://doi.org/10.1016/j.ympev.2009.04.020
Pavlicev, M., Wagner, G. P., & Cheverud, J. M. (2009). Measuring Evolutionary Constraints Through the Dimensionality of the Phenotype: Adjusted Bootstrap Method to Estimate Rank of Phenotypic Covariance Matrices. Evolutionary Biology, 36(3), 339-353. https://doi.org/10.1007/s11692-009-9066-7
Pavlicev, M., Cheverud, J. M., & Wagner, G. P. (2009). Measuring Morphological Integration Using Eigenvalue Variance. Evolutionary Biology, 36(1), 157-170. https://doi.org/10.1007/s11692-008-9042-7
2008
Norgard, E. A., Roseman, C. C., Fawcett, G. L., Pavlicev, M., Morgan, C. D., Pletscher, L. S., Wang, B., & Cheverud, J. M. (2008). Identification of quantitative trait loci affecting murine long bone length in a two-generation intercross of LG/J and SM/J Mice. Journal of Bone and Mineral Research, 23(6), 887-95. https://doi.org/10.1359/jbmr.080210
Pavlicev, M., Kenney-Hunt, J. P., Norgard, E. A., Roseman, C. C., Wolf, J. B., & Cheverud, J. M. (2008). Genetic variation in pleiotropy: differential epistasis as a source of variation in the allometric relationship between long bone lengths and body weight. Evolution, 62(1), 199-213. https://doi.org/10.1111/j.1558-5646.2007.00255.x
Wagner, G. P., Kenney-Hunt, J. P., Pavlicev, M., Peck, J. R., Waxman, D., & Cheverud, J. M. (2008). Pleiotropic scaling of gene effects and the 'cost of complexity'. Nature, 452(7186), 470-2. https://doi.org/10.1038/nature06756
Showing entries 41 - 60 out of 64