Mihaela Pavličev

Mihaela Pavličev

Univ.-Prof. Mag. Dr.

Deputy Head of the Department of Evolutionary Biology

Head of the Unit for Theoretical Biology

phone +43-1-4277-56700
mihaela.pavlicev@univie.ac.at

External links

Profile in ResearchGate

Profile in Google Scholar

Teaching at the Univ. Vienna

About me

My foremost interest is in the organismal features that enable evolvability of complex organisms. To understand phenotypic evolution, we need to understand what patterns of heritable phenotypic variation the developmental/physiological systems are able to produce, what are the consequences of specific patterns of variation over short terms (population genetic scale) and long terms (species divergence observed in comparative biology) under selection and drift, and how the patterns of variation themselves evolve.

One recurring evolutionary phenomenon is the decoupling of variation between traits, and subsequent individuation of parts and the origin of new biological units. In this context, my work pertains to the role of pleiotropy and interactions in this process.

I pursue these questions of evolvability and individuation in theory as well as in empirical work on the evolution of limbs and of the mammalian female reproductive system.

Publications

2017

Pavličev, M., Wagner, G. P., Chavan, A. R., Owens, K., Maziarz, J., Dunn-Fletcher, C., Kallapur, S. G., Muglia, L., & Jones, H. (2017). Single-cell transcriptomics of the human placenta: inferring the cell communication network of the maternal-fetal interface. Genome Research, 27(3), 349-361. https://doi.org/10.1101/gr.207597.116

Simonti, C. N., Pavlicev, M., & Capra, J. A. (2017). Transposable Element Exaptation into Regulatory Regions Is Rare, Influenced by Evolutionary Age, and Subject to Pleiotropic Constraints. Molecular Biology and Evolution, 34(11), 2856-2869. https://doi.org/10.1093/molbev/msx219

Wagner, G. P., & Pavličev, M. (2017). Origin, Function, and Effects of Female Orgasm: All Three are Different. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 328(4), 299-303. https://doi.org/10.1002/jez.b.22737

Zhang, G., Feenstra, B., Bacelis, J., Liu, X., Muglia, L. M., Juodakis, J., Miller, D. E., Litterman, N., Jiang, P. P., Russell, L., Hinds, D. A., Hu, Y., Weirauch, M. T., Chen, X., Chavan, A. R., Wagner, G. P., Pavličev, M., Nnamani, M. C., Maziarz, J., ... Muglia, L. J. (2017). Genetic Associations with Gestational Duration and Spontaneous Preterm Birth. New England Journal of Medicine, 377(12), 1156-1167. https://doi.org/10.1056/NEJMoa1612665

2016

Arendt, D., Musser, J. M., Baker, C. V. H., Bergman, A., Cepko, C., Erwin, D. H., Pavlicev, M., Schlosser, G., Widder, S., Laubichler, M. D., & Wagner, G. P. (2016). The origin and evolution of cell types. Nature Reviews. Genetics, 17(12), 744-757. https://doi.org/10.1038/nrg.2016.127

Eidem, H. R., Rinker, D. C., Ackerman, W. E., Buhimschi, I. A., Buhimschi, C. S., Dunn-Fletcher, C., Kallapur, S. G., Pavličev, M., Muglia, L. J., Abbot, P., & Rokas, A. (2016). Comparing human and macaque placental transcriptomes to disentangle preterm birth pathology from gestational age effects. Placenta, 41, 74-82. https://doi.org/10.1016/j.placenta.2016.03.006

Gonzalez, P. N., Pavlicev, M., Mitteroecker, P., Pardo-Manuel de Villena, F., Spritz, R. A., Marcucio, R. S., & Hallgrímsson, B. (2016). Genetic structure of phenotypic robustness in the collaborative cross mouse diallel panel. Journal of Evolutionary Biology, 29(9), 1737-1751. https://doi.org/10.1111/jeb.12906

Kin, K., Maziarz, J., Chavan, A. R., Kamat, M., Vasudevan, S., Birt, A., Emera, D., Lynch, V. J., Ott, T. L., Pavlicev, M., & Wagner, G. P. (2016). The Transcriptomic Evolution of Mammalian Pregnancy: Gene Expression Innovations in Endometrial Stromal Fibroblasts. Genome Biology and Evolution, 8(8), 2459-2473. https://doi.org/10.1093/gbe/evw168

Mitteroecker, P., Huttegger, S. M., Fischer, B., & Pavlicev, M. (2016). Cliff-edge model of obstetric selection in humans. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 113(51), 14680-14685. https://doi.org/10.1073/pnas.1612410113

Mitteroecker, P., Cheverud, J. M., & Pavlicev, M. (2016). Multivariate Analysis of Genotype-Phenotype Association. Genetics: a periodical record of investigations bearing on heredity and variation, 202(4), 1345-1363. https://doi.org/10.1534/genetics.115.181339

Pavličev, M., Mitteroecker, P., Gonzalez, P. M., Rolian, C., Jamniczky, H., Villena, F. P. M., Marcucio, R., Spritz, R., & Hallgrimsson, B. (2016). Development Shapes a Consistent Inbreeding Effect in Mouse Crania of Different Line Crosses. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 326(8), 474-488. https://doi.org/10.1002/jez.b.22722

Pavličev, M., & Wagner, G. (2016). The Evolutionary Origin of Female Orgasm. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 326(6), 326-337. https://doi.org/10.1002/jez.b.22690

2015

Pavlicev, M., Hiratsuka, K., Swaggart, K. A., Dunn, C., & Muglia, L. (2015). Detecting endogenous retrovirus-driven tissue-specific gene transcription. Genome Biology and Evolution, 7(4), 1082-1097. https://doi.org/10.1093/gbe/evv049

Pavlicev, M., & Widder, S. (2015). Wiring for Independence: Positive Feedback Motifs Facilitate Individuation of Traits in Development and Evolution. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 324(2), 104-113. https://doi.org/10.1002/jez.b.22612

Swaggart, K. A., Pavlicev, M., & Muglia, L. J. (2015). Genomics of preterm birth. In Cold Spring Harbor Perspectives in Medicine (2 ed., Vol. 5, pp. a023127). Cold Spring Harbor perspectives in medicine https://doi.org/10.1101/cshperspect.a023127